这世上咋有这么脑残的电瓶车车主？
今天下午1点半发现一辆电瓶车，停在了燃气管道边上，当时就是卧槽，太威胁了，就跟物业反应这个问题。十几分钟物业没回复，想了下，我还是亲自把电瓶车移出来，太危险了。过了半个小时，物业回复：这个车主经常把电瓶车停在燃气管道边上。
A pangenome reference of 36 Chinese populations.pdf
A pangenome reference of 36 Chinese populations.PDF
中国36个群体的pangenome参考
Human genomics is witnessing an ongoing paradigm shift from a single reference sequence to a pangenome form, but populations of Asian ancestry are underrepresented. Here we present data from the first phase of the Chinese Pangenome Consortium, including a collection of 116 high-quality and haplotype-phased de novo assemblies based on 58 core samples representing 36 minority Chinese ethnic groups. With an average 30.65× high-fidelity long-read sequence coverage, an average contiguity N50 of more than 35.63 megabases and an average total size of 3.01 gigabases, the CPC core assemblies add 189 million base pairs of euchromatic polymorphic sequences and 1,367 protein-coding gene duplications to GRCh38. We identified 15.9 million small variants and 78,072 structural variants, of which 5.9 million small variants and 34,223 structural variants were not reported in a recently released pangenome reference1. The Chinese Pangenome Consortium data demonstrate a remarkable increase in the discovery of novel and missing sequences when individuals are included from underrepresented minority ethnic groups. The missing reference sequences were enriched with archaic-derived alleles and genes that confer essential functions related to keratinization, response to ultraviolet radiation, DNA repair, immunological responses and lifespan, implying great potential for shedding new light on human evolution and recovering missing heritability in complex disease mapping.
